Decomposition products of cylindrospermopsin – a cyanotoxin produced by Raphidiopsis raciborskii (Woloszynska)

Michal Adamski, Paweł Żmudzki, Jan Bialczyk, Ariel Kaminski, Ewelina Chrapusta-Srebrny, Beata Bober, Kornelia Duchnik

Paper category: Original research paper
Corresponding author: Michal Adamski (
DOI: 10.2478/ohs-2019-00020
Received: 25/01/2019
Accepted: 13/03/2019
Full text: here

Citation: Adamski, M., Żmudzki, P., Bialczyk, J., et al. (2019). Decomposition products of cylindrospermopsin – a cyanotoxin produced by Raphidiopsis raciborskii (Woloszynska). Oceanological and Hydrobiological Studies, 48(3), pp. 227-235. Retrieved 3 Oct. 2019, from doi:10.2478/ohs-2019-0020


Toxins produced by cyanobacteria (cyanotoxins) and released into water have become a serious problem worldwide due to the increasing morbidity and mortality of living organisms they have caused. The ability to synthesize the cytotoxic alkaloid cylindrospermopsin (CYN) has been demonstrated in several freshwater species of cyanobacteria. CYN is highly chemically stable under environmental factors and decomposes only under alkaline conditions, where it forms derivatives. The toxicity potential of the decomposition products formed at pH 10 combined with high temperature (100°C) or UV-B irradiation (36 µmol m<sup>−2</sup> s<sup>−1</sup>) has been research based on the crustacean Thamnocephalus platyurus (Thamnotoxkit FTM) and bacteria Vibrio fischeri (Deltatox® II) bioassays. This paper is a continuation and completion of our previous experiments and the obtained results showed that the applied conditions contributed to the decomposition of the CYN molecule to non-toxic products and its structural modifications by separating the uracil ring or/and the sulfate group from the tricyclic guanidine moiety, leading to a reduction in its toxicity. To the best of our knowledge, this is the first report describing the toxicity of CYN decomposition products formed under alkaline conditions combined with boiling temperature or UV-B irradiation.


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